Mathematics

Traveling pulses with oscillatory tails, figure-eight stack of isolas, and dynamics in heterogeneous media

Speaker: 
Yasumasa Nishiura
Date: 
Wed, May 12, 2021
Location: 
UBC, Vancouver, Canada
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

The interplay between 1D traveling pulses with oscillatory tails (TPO) and heterogeneities of bump type is studied for a generalized three-component FitzHugh-Nagumo equation. We first present that stationary pulses with oscillatory tails (SPO) forms a “snaky" structure in homogeneous space, then TPO branches take a form of "figure-eight-like stack of isolas" located close to the snaky structure of SPO. Here we adopt voltage-difference as a bifurcation parameter. A drift bifurcation from SPO to TPO can be found by introducing another parameter at which these two solution sheets merge. As for the heterogeneous problem, in contrast to monotone tail case, there appears a nonlocal interaction between the TPO and the heterogeneity that creates infinitely many saddle solutions. The response of TPO shows a variety of dynamics including pinning and depinning processes in addition to penetration and rebound. Stable/unstable manifolds of these saddles interact with TPO in a complex way, which causes a subtle dependence on the initial condition and a difficulty to predict the behavior after collision even in one-dimensional space. Nevertheless, for 1D case, a systematic global exploration of solution branches (HIOP) induced by heterogeneities, and the reduction method to finite-dimensional ODEs allow us to clarify such a subtle dependence of initial condition and detailed mechanism of the transitions from penetration to pinning and pinning to rebound from dynamical system view point. It turns out that the basin boundary between two different outputs against the heterogeneities forms an infinitely many successive reconnections of heteroclinic orbits among those saddles as the height of the bump is changed, which causes the subtle dependence of initial condition. This is a joint work with Takeshi Watanabe.

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Symmetries and bifurcations in non-local cell adhesion models

Speaker: 
Thomas Hillen
Date: 
Thu, May 13, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

Cellular adhesion is one of the most important interaction forces between cells and other tissue components. In 2006, Armstrong, Painter and Sherratt introduced a non-local PDE model for cellular adhesion, which was able to describe known experimental results on cell sorting and pattern formation. The pattern formation arises through non-local attractive interactions of the cells. In this talk I will analyse the underlying symmetries and bifurcations that lead to the observed patterns. (joint work with A. Buttenschoen).

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Patterns, waves and bufurcations in cell migration

Speaker: 
Leah Edelstein-Keshet
Andreas Buttenschoen
Date: 
Thu, May 13, 2021
Location: 
UBC
Online
Conference: 
PIMS Workshop on New Trends in Localized Patterns in PDES
Abstract: 

Cell migration plays a central roles in embryonic development, wound healing and immune surveillance. In 2008, Yoichiro Mori, Alexandra Jilkine and LEK published a reaction-diffusion model for the initial step of cell migration, the front-back chemical polarization that sets a cell's directionality. (More detailed mathematical properties of this model were described by the same group in 2011.) Since then, progress has been made in investigating how that simple "wave-pinning" mechanism is shaped and tuned by feedback from other proteins, from the cell's environment (extracellular matrix), from interplay with larger signaling networks, and from cell-cell interactions. In this talk, we will describe some of this progress and mathematical questions that arise. In particular, AB will demonstrate how his numerical PDE bifurcation analysis has helped us to understand how cells repolarize to reverse their direction of motion.

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Towards optimal spectral gaps in large genus

Speaker: 
Michael Lipnowski
Date: 
Thu, May 13, 2021
Location: 
Zoom
Online
Conference: 
Pacific Dynamics Seminar
Abstract: 

I'll discuss recent joint work with Alex Wright (arXiv:
2103.07496
) showing that typical large genus hyperbolic surfaces have first
Laplacian eigenvalue at least 3/16−ϵ.

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Classification and rigidity for group von Neumann algebras.

Speaker: 
Adrian Ioana
Date: 
Tue, May 4, 2021
Location: 
Online
University of Regina
Abstract: 

Any countable group G gives rise to a von Neumann algebra L(G). The classification of these group von Neumann algebras is a central theme in operator algebras. I will survey recent rigidity results which provide instances when various algebraic properties of groups, such as the presence or absence of a direct product decomposition, are remembered by their von Neumann algebras. I will also explain the strongest such rigidity results, where L(G) completely remembers G, and discuss some of the open problems in the area.

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Remarks on multi-marginals entropic optimal transport and Sinkhorn algorithm

Speaker: 
Guillaume Carlier
Date: 
Thu, May 6, 2021
Location: 
Zoom
Online
Conference: 
Kantorovich Initiative Seminar
Abstract: 

Entropic optimal transport has received a lot of attention in recent years and has become a popular framework for computational optimal transport thanks to the Sinkhorn scaling algorithm. In this talk, I will discuss the multi-marginal case which arises in different applied contexts in physics, economics and machine learning. I will show in particular that the multi-marginal Schrödinger system is well posed (joint work with Maxime Laborde) and that the multi-marginal Sinkhorn algorithm converges linearly.

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Random Hyperbolic Surfaces Via Flat Geometry

Speaker: 
Aaron Calderon
Date: 
Thu, May 6, 2021
Location: 
Online
Zoom
PIMS, University of Washington
Conference: 
Pacific Dynamics Seminar
Abstract: 

Mirzakhani gave an inductive procedure to build random hyperbolic surfaces by gluing together smaller random pieces along curves. She proved that as the length of the gluing curve grows, these families equidistribute in the moduli space of hyperbolic surfaces. In this talk, I’ll explain how the conjugacy (exposited in James’s talk) between the earthquake and horocycle flows provides a template for translating equidistribution results for flat surfaces into equidistribution results for hyperbolic ones. Using this correspondence, we address Mirzakhani’s twist torus conjecture and exhibit new limiting distributions for hyperbolic surfaces built out of symmetric pieces. This is joint work (in progress) with James Farre.

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Optimal curvature in long-range cell-cell communication

Speaker: 
Jun Allard
Date: 
Wed, May 5, 2021
Location: 
Zoom
Online
PIMS, University of British Columbia
Conference: 
Mathematical Biology Seminar
Abstract: 

Cells in tissue can communicate short-range via direct contact, and long-range via diffusive signals. In addition, another class of cell-cell communication is by long, thin cellular protrusions that are ~100 microns in length and ~100 nanometers in width. These so-called non-canonical protrusions include cytonemes, nanotubes, and airinemes. But, before establishing communication, they must find their target cell. Here we demonstrate airinemes in zebrafish are consistent with a finite persistent random walk model. We study this model by stochastic simulation, and by numerically solving the survival probability equation using Strang splitting. The probability of contacting the target cell is maximized for a balance between ballistic search (straight) and diffusive (highly curved, random) search. We find that the curvature of airinemes in zebrafish, extracted from live cell microscopy, is approximately the same value as the optimum in the simple persistent random walk model. We also explore the ability of the target cell to infer direction of the airineme’s source, finding the experimentally observed parameters to be at a Pareto optimum balancing directional sensing with contact initiation.

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Conjugating flows on the moduli of hyperboic and flat surfaces

Speaker: 
James Farre
Date: 
Thu, Apr 29, 2021
Location: 
Zoom
Online
Conference: 
Pacific Dynamics Seminar
Abstract: 

A measured geodesic lamination on a hyperbolic surface encodes the
horizontal trajectory structure of certain quadratic differentials.
Thurston’s earthquake flow along such a lamination induces a dynamical
system on the moduli space of hyperbolic surfaces sharing many properties
with the classical Teichmüller horocycle flow. Mirzakhani gave a dynamical
correspondence between the earthquake and horocycle flows, defined
Lebesgue-almost everywhere. In this talk, we extend Mirzakhani’s conjugacy
and define an extension of the earthquake flow to an action of the upper
triangular group P in PSL(2,R) mapping certain flow lines to Teichmüller
geodesics. We classify the P-invariant ergodic probability measures as
those coming from affine invariant measures on quadratic differentials and
show that our map is a measurable isomorphism between P actions with
respect to these measures. This is joint work with Aaron Calderon.

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Cell symmetry breaking for movement through a mechanochemical mechanism

Speaker: 
Calina Copos
Date: 
Wed, Apr 28, 2021
Location: 
Zoom
Online
PIMS, University of British Columbia
Conference: 
Mathematical Biology Seminar
Abstract: 

To initiate movement, cells need to form a well-defined "front" and "rear" through the process of cellular polarization. Polarization is a crucial process involved in embryonic development and cell motility and it is not yet well understood. Mathematical models that have been developed to study the onset of polarization have explored either biochemical or mechanical pathways, yet few have proposed a combined mechano-chemical mechanism. However, experimental evidence suggests that most motile cells rely on both biochemical and mechanical components to break symmetry. I will describe a mechano-chemical mathematical model for emergent organization driven by both cytoskeletal dynamics and biochemical reactions. We have identified one of the simplest quantitative frameworks for a possible mechanism for spontaneous symmetry breaking for initiation of cell movement. The framework relies on local, linear coupling between minimal biochemical stochastic and mechanical deterministic systems; this coupling between mechanics and biochemistry has been speculated biologically, yet through our model, we demonstrate it is a necessary and sufficient condition for a cell to achieve a polarized state.

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