Mathematics

In recent years it has become increasingly clear that stochasticity plays an important role in many biological processes. Examples include bistable genetic switches, noise enhanced robustness of oscillations, and fluctuation enhanced sensitivity or “stochastic focusing". Numerous cellular systems rely on spatial stochastic noise for robust performance. We examine the need for stochastic models, report on the state of the art of algorithms and software for modeling and simulation of stochastic biochemical systems, and identify some computational challenges.

The dichotomy between sparse and dense structures is one of the profound, yet fuzzy, features of contemporary mathematics and computer science. We present a framework for this phenomenon, which equivalently defines sparsity and density of structures in many different yet equivalent forms, including effective decomposition properties. This has several applications to model theory, algorithm design and, more recently, to structural limits.

A planar set that contains a unit segment in every direction is called a Kakeya set. These sets have been studied intensively in geometric measure theory and harmonic analysis since the work of Besicovich (1928); we find a new connection to game theory and probability. A hunter and a rabbit move on an n-vertex cycle without seeing each other until they meet. At each step, the hunter moves to a neighboring vertex or stays in place, while the rabbit is free to jump to any node. Thus they are engaged in a zero sum game, where the payoff is the capture time. We show that every rabbit strategy yields a Kakeya set; the optimal rabbit strategy is based on a discretized Cauchy random walk, and it yields a Kakeya set K consisting of 4n triangles, that has minimal area among such Kakeya sets. Passing to the scaling limit yields a simple construction of a random Kakeya set with zero area from two Brownian motions. (Talk based on joint work withY. Babichenko, R. Peretz, P. Sousi and P. Winkler).