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A Quantitative Systems Pharmacology Model of the Immune Response to SARS-COV-2

Speaker: Wei Dai, Rohit Rao

Date: Wed, Jun 24, 2020

Location: Zoom

Conference: CAIMS - PIMS Coronavirus Modelling Conference

Subject: Mathematics, Mathematical Biology

Class: Scientific

Abstract:

Rapid development of a QSP model to support novel COVID-19 therapies. We intend to publish this model quickly to encourage community feedback. The simulated dynamics of immune response are modeled by describing viral activation of innate and adaptive immune processes involving both pro-inflammatory mediators regulating viral clearance and cell damage (e.g. neutrophils and cytotoxic lymphocytes) as well as counter-regulatory immune suppressive mediators (e.g. Treg cells and IL-10).